It occurred to me this afternoon that this line might offend some, so I decided to explain it without apologizing. I meant the line androgynously. It's also an homage to the Dan Ackroyd and Jane Curtain days on SNL and their Weekend Update skits.
It's also worth quoting Saint Nancy. She loved the line, and I asked her in a response thread about whether others would understand my intent, she said:
"I think of this the same way I think of the word cunt. It’s more sexist to assume it only applies to women. I can’t encourage censoring yourself to accommodate everyone’s sensitivities."